QIAseq Multimodal Panels
- Complete system to go from total nucleic acids to a sequencing-ready library using a single-day workflow
- Error correction with Unique Molecular Indices (UMIs) to enhance NGS panel sensitivity
- A single-primer extension (SPE) approach that overcomes the limitations of 2-primer amplicon approaches on amplicon size and primer multiplexing
- Unique Dual Indices (UDIs) to reduce sample index hopping
- Sample to Insight solution for consolidated targeted DNA and RNA sequencing
QIAseq Multimodal Panels have been developed for consolidated targeted DNA and RNA enrichment and analyses. Unlike current approaches, QIAseq Multimodal Panels do not require 2 separate workflows for DNA and RNA analysis – saving time and conserving samples that are of limited availability.
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Cat No./ID:333932 QIAseq Multimodal Panel (12) $3,024.00 Kit containing ALL reagents (except indices) sufficient to process 12 samples for multimodal (DNA and RNA) sequencing; fixed small panel for a total of 24 reactions |
Cat No./ID:333935 QIAseq Multimodal Panel (96) $17,630.00 Kit containing ALL reagents (except indices) sufficient to process 96 samples for multimodal (DNA and RNA) sequencing; fixed small panel for a total of 192 reactions |
Cat No./ID:333942 QIAseq Multimodal HC Panel (12) $8,388.00 Kit containing ALL reagents (except indices) sufficient to process 12 samples for multimodal (DNA and RNA) sequencing; fixed high content (HC) panel for a total of 24 reactions |
Cat No./ID:333945 QIAseq Multimodal HC Panel (96) $63,744.00 Kit containing ALL reagents (except indices) sufficient to process 96 samples for multimodal (DNA and RNA) sequencing; fixed high content (HC) panel for a total of 192 reactions |
Cat No./ID:333962 QIAseq Multimodal Index I (12) $800.00 Box containing indices, enough to process a total of 12 samples, for indexing up to a total of 12 samples for QIAseq Multimodal Panel sequencing on Illumina platforms |
Cat No./ID:333965 QIAseq Multimodal Index I Set A (96) $3,022.00 Box containing indices, enough to process a total of 96 samples, for indexing up to a total of 96 samples for QIAseq Multimodal Panel sequencing on Illumina platforms; 1 of 2 sets required for multiplexing 192 samples |
Cat No./ID:333975 QIAseq Multimodal Index I Set B (96) $3,022.00 Box containing indices, enough to process a total of 96 samples, for indexing up to a total of 96 samples for QIAseq Multimodal Panel sequencing on Illumina platforms; 2 of 2 sets required for multiplexing 192 samples |
Cat No./ID:333985 QIAseq Multimodal Index I Set A SW (96) $3,022.00 Box containing indices, enough to process a total of 96 samples, for indexing up to a total of 96 samples for QIAseq Multimodal Panel sequencing on Illumina platforms using the optional separate workflows; 1 of 2 sets required for multiplexing 192 samples |
Cat No./ID:333995 QIAseq Multimodal Index I Set B SW (96) $3,022.00 Box containing indices, enough to process a total of 96 samples, for indexing up to a total of 96 samples for QIAseq Multimodal Panel sequencing on Illumina platforms using the optional separate workflows; 2 of 2 sets required for multiplexing 192 samples |
Product Details
Recent advances in NGS chemistries, platforms, and bioinformatics pipelines are enabling users to efficiently interrogate biological samples for changes in DNA and RNA. Current approaches, however, require the use of 2 separate workflows to prepare libraries from separate DNA and RNA isolates. Limitations of such approaches include:
- Large amounts of sample material required for generating sufficient amounts of input DNA and RNA for multiple workflows
- Added complexity of deriving integrated insights from results of different technical approaches, each with its own innate bias
- Inefficient use of resources
- Long turn-around times
To overcome the limitations associated with current approaches, QIAseq Multimodal Panels start with total nucleic acids (or DNA + RNA) and prepares UDI-containing, Illumina-compatible targeted DNA and RNA libraries using a single-day, consolidated workflow. In addition, QIAseq Multimodal Panels have been designed for use with low-yield and poor-quality biological samples.
Workflow of the QIAseq Multimodal Panels
The QIAseq Multimodal Panel workflow can be used to prepare sequencing-ready libraries in a single day. The library insert size is approximately 150 bp, making the QIAseq Multimodal Panels highly compatible with low-quality samples, such as FFPE samples.
Robust detection of DNA and RNA biomarkers
QIAseq Multimodal Panels can be used to reliably detect DNA and RNA biomarkers using a consolidated workflow from total nucleic acids. The ability of QIAseq Multimodal Panels to simultaneously detect DNA and RNA biomarkers has been benchmarked against two separate workflows (namely, QIAseq Targeted DNA and QIAseq Targeted RNAscan Panels).
QIAseq Multimodal Panels can be used to interrogate different types of biomarkers using a consolidated workflow from total nucleic acids, which can be isolated using dedicated sample isolation protocols that have been developed specifically for the QIAseq Multimodal Panels.
From DNA:
- Single nucleotide variants (SNVs)
- Insertions and Deletions (InDels)
- Copy number variants (CNVs)
From RNA:
- Fusions
- Exon skipping events
- Gene expression levels
Product Resources
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QIAseq DNA QuantiMIZE Assay Kit
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AllPrep DNA/RNA FFPE Kit (50)
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QIAquick Gel Extraction Kit (1000)
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Deparaffinization Solution (16 ml)
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GeneRead DNA FFPE Kit
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HotStarTaq DNA Polymerase (1000 U)
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QIAquick Spin Columns (100)
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Buffer EB (250 ml)
250 ml Elution Buffer$36.10Add To Cart - Cat No./ID:972804
PyroMark Gold Q96 Reagents (5 x 96)
For performing Pyrosequencing reactions on the PyroMark Q96 ID (5 x 96) and PyroMark Q96 MD (15 x 96)$601.00Add To Cart - Cat No./ID:74106
RNeasy Mini Kit (250)
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